Table 4.
Improvement effects of polyphenol nanoformulation using polymer.
| Materials | Polyphenols | Drug Release | Target | Improvement | Ref. |
|---|---|---|---|---|---|
| Polymer | Hesperestin | ~45% at pH 7.4 <20% at pH 3 (~72 h) |
HCT15 Human colon cancer cell |
IC50 28 μM (6.7-fold↓) Apoptosis 2.4-fold↑ Bax and Bad mRNA 35%↑ |
[72] |
| Quercetin | No release at < pH 4.5 (~2 h) 90% at pH 7.4 (~20 h) |
CT26 colon cancer cell |
IC50 0.8 μM (81-fold↓) Cell viability 40%↓ |
[73] | |
| Curcumin | ~28% at pH 7.4 (~90 min) |
A549 Human lung cancer |
Solubility 14-fold↑ IC50 44 µM (3-fold↓) |
[74] | |
| ~25% at pH 5 ~72% at pH 7.4 (~30 h) |
4T1 cancer cell HeLa cell |
IC50 4–9 µg/mL Half-life 6.16 h (14-fold↑) Tumor growth 27%↓ |
[75] | ||
| Quercetin | 95% at pH 7.4 (with serum, ~48 h) |
PCa cell lines (PC-3 and LNCaP) |
IC50 36–82%↓ Caspase 3 activation↑ in vivo tumor growth 40%↓ |
[76] | |
| Curcumin | ~69% at pH 4.5 ~37% at pH 7.4 (~24 h) |
MCF-7 cell MCF-7/Adr cell |
Reduction of drug efflux IC50 14.8-fold↓ Apoptosis 4.6-fold↑ Tumor inhibition 55.2% (2-fold↑) |
[77] | |
| Resveratrol and curcumin |
Earlier in pH 5.4 than pH 7 |
SH-SY5Y cancer cell | Cytotoxicity 37%↑ Intracellular calcium release 20%↑ Cytochrome C oxidase activation↓ Mitochondrial depolarization |
[78] |
↑: Increase in some effects; ↓: Decrease in some effects.