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(A) Alignment of the S. cerevisiae and human Cdc42p effector domains. Arrows point to the specific amino acid changes (one-letter code) made at positions 32, 37, 38, 40, and 44. (B) Cdc42p crystal structure (adapted from reference 27). Highlighted in yellow are amino acids 26 to 50 of the effector domain. Highlighted in green are Tyr32 and Tyr40, in blue is Phe37, in red is Asp38, and in purple is Val44.
