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. 2023 May 22;15(10):2858. doi: 10.3390/cancers15102858
ICIs immune checkpoint inhibitors
MSI-H microsatellite instability-high
FDA The United States Food and Drug Administration
NSCLC non-small cell lung cancer
EGFR-TKI epidermal growth factor receptor-tyrosine kinase inhibitor
Tregs regulatory T cells
LAG-3 lymphocyte activation gene-3
TIM-3 T cell immunoglobulin and mucin domain-3
Tight T cell immunoglobulin and ITIM domain
PFS progression-free survival
TME tumor microenvironment
VEGF vascular endothelial growth factor
HCC hepatocellular carcinoma
OS overall survival
mPFS median PFS
mOS median OS
RCC renal cell carcinoma
mCRC metastatic colorectal carcinoma
ORR objective response rate
EGFR epidermal growth factor receptor
HER2 human epidermal growth factor receptor 2
DOR duration of response
T-DM1 trastuzumab emtansine
ADCs antibody-drug conjugates
PARP poly ADP-ribose polymerase
HRR homologous recombination repair
HRD homologous recombination deficiency
TMB tumor mutation burden
TNBC triple-negative breast cancer
TPS tumor proportion score
AR androgen receptor
ER estrogen receptor
PR progesterone receptor
HR+/HER2− hormone receptor positive/HER2 negative
CDKs cyclin-dependent kinases
ALK anaplastic lymphoma kinase
CAR-T Chimeric antigen receptor T cell
NK Natural killer