Table 2.

Characteristics of various AML target molecules (ADP: adenosine diphosphate; CLL-1: C-type lectin-like molecule-1; CTL: cytotoxic T cell; DC: dendritic cell; HSC: hematopoietic stem cell; LSC: leukemic stem cell; NK: natural killer; TNF: tumor necrosis factor).

Target Antigen	Function	Expression on Normal Cells	Expression on HSCs	Expression on LSCs
CLL-1	Glycoprotein, Transmembrane receptor	Myeloid, lung, epithelial cells	-	+
CD 33	SIGLEC family protein, Transmembrane receptor	Progenitor, myeloid, Kupffer cells	+	+
CD 7	Ig superfamily/Glycoprotein, B and T cell lymphoid development, Transmembrane protein	T, NK cells, and myeloid progenitor	-	+
FLT3	Type III cytokine receptor, Tyrosine kinase receptor	Neurons, testis	+	+
CD 38	Glycoprotein, Cyclic ADP ribose hydroxylase	B, T, NK cells	-	+
CD 123	Type I cytokine receptor of IL-3, IL3 receptor subunit	Myeloid progenitors, DC, and basophils	+	+
CD 44v6	Glycoprotein, Transmembrane receptor	Keratinocytes	-	+
LeY	Glycosphingolipid, Blood group Ag	Intestinal epithelial cells	+	+
NKG2D	C-type lectin-like receptor protein, Activator receptor	NK, NKT, Tαδ, Th, and CTL	-	+
CD 70	Glycoprotein from the TNF family, Transmembrane receptor	T and B cells	-	+
CD 96	Member of immunoglobulin superfamily, adhesion of activated T and NK cells	T cells and NK cells	-	+