Table 1.
Platelet 5-HT concentration and platelet MAO-B activity in control subjects and asthma patients carrying different genotypes and alleles of the HTR2A (rs6314 and rs6313), and HTR2C (rs3813929 and rs518147), as well as MAOB (rs1799836 and rs6651806) polymorphisms, respectively.
| SNP | Platelet 5-HT Concentration (nmol/mg Protein) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HTR2A/C | Genotypes | Carriers | Carriers | |||||||
| rs6314 | AA | AG | GG | A | GG | G | AA | |||
| Control subjects | 1.52 0.93; - |
1.04 0.75; 1.70 |
0.91 0.69; 1.54 |
p = 0.28 | 1.04 0.78; 1.80 |
0.91 0.69; 1.54 |
p = 0.14; U = 1257.0 |
0.96 0.71; 1.63 |
1.52 0.93; - |
p = 0.42; U = 75.0 |
| Asthma patients | 0.79 0.79; 0.7 |
0.88 0.69; 1.19 |
0.79 0.59; 1.07 |
p = 0.41 | 0.85 0.69; 1.18 |
0.79 0.59; 1.07 |
p = 0.19; U = 1079.0 |
0.82 0.62; 1.09 |
0.79 0.79; 0.79 |
p = 0.97; U = 57.0 |
| rs6313 | AA | AG | GG | A | GG | G | AA | |||
| Control subjects | 0.94 0.73; 1.6 |
1.01 0.74; 1.54 |
0.92 0.70; 1.66 |
p = 0.97 | 0.98 0.74; 1.61 |
0.92 0.70; 1.66 |
p = 0.84; U = 1522.0 |
0.98 0.71; 1.61 |
0.94 0.73; 1.68 |
p = 0.85; U = 1179.0 |
| Asthma patients | 0.81 0.62; 1.1 |
0.75 0.61; 1.09 |
0.89 0.65; 1.09 |
p = 0.39 | 0.76 0.62; 1.09 |
0.89 0.65; 1.09 |
p = 0.22; U = 1487.0 |
0.82 0.62; 1.09 |
0.81 0.62; 1.15 |
p = 0.90; U = 1022.0 |
| rs3813929 | CC | CT | TT | C | TT | T | CC | |||
| Control subjects | 1.03 0.74; 1.66 |
0.86 0.66; 1.22 |
0.92 0.78; 1.53 |
p = 0.54 | 0.98 0.71; 1.66 |
0.92 0.78; 1.53 |
p = 1.00; U = 742.0 |
0.90 0.70; 1.28 |
1.03 0.74; 1.66 |
p = 0.40; U = 1182.0 |
| Asthma patients | 0.82 0.55; 1.09 |
0.76 0.64; 1.12 |
0.76 0.56; 0.97 |
p = 0.83 | 0.82 0.62; 1.09 |
0.76 0.56; 0.97 |
p = 0.60; U = 299.0 |
0.76 0.64; 1.10 |
0.82 0.55; 1.09 |
p = 0.97; U = 1110.0 |
| rs518147 | CC | CG | GG | C | GG | G | CC | |||
| Control subjects |
1.04 0.80; 2.05 |
0.86 0.68; 1.13 |
0.99 0.65; 1.60 |
p = 0.20 | 0.94 0.73; 1.67 |
0.99 0.65; 1.60 |
p = 0.70; U = 1720.0 |
0.94 0.68; 1.55 |
1.04 0.80; 2.05 |
p = 0.12; U = 1220.0 |
| Asthma patients | 0.82 0.59; 1.08 |
0.76 0.66; 1.11 |
0.79 0.58; 1.09 |
p = 0.78 | 0.82 0.64; 1.09 |
0.79 0.58; 1.09 |
p = 0.50; U = 1661.0 |
0.78 0.61; 1.09 |
0.82 0.59; 1.08 |
p = 0.74; U = 1500.0 |
| MAOB | Platelet MAO-B activity (nmol/mg of protein per hour) | |||||||||
| rs1799836 | CC | CT | TT | T | CC | C | TT | |||
| Control subjects | 36.72 25.80; 59.67 |
40.94 31.52; 52.86 |
28.08 22.58; 41.41 |
p = 0.013 | 32.23 25.70; 51.08 |
36.72 25.80; 59.67 |
p = 0.40; U = 1532.0 |
38.85 28.61; 58.44 |
28.08 22.58; 41.41 |
p = 0.008 U = 1256.0 |
| Asthma patients | 41.45 31.22; 54.13 |
46.42 35.21; 65.73 |
41.45 34.66; 56.16 |
p = 0.11 | 43.76 35.26; 61.56 |
41.45 31.22; 54.13 |
p = 0.14; U = 1257.0 |
44.72 34.07; 58.94 |
41.45 34.66; 56.16 |
p = 0.59; U = 1602.5 |
| rs6651806 | AA | AC | CC | A | CC | C | AA | |||
| Control subjects | 29.81 25.07; 51.12 |
41.92 31.52; 61.61 |
30.24 21.77; 49.29 |
p = 0.03 | 34.13 25.73; 51.31 |
30.24 21.77; 49.29 |
p = 0.55; U = 1129.0 |
36.88 28.99; 58.69 |
29.81 25.07; 51.12 |
p = 0.10; U = 1438.0 |
| Asthma patients | 41.63 34.01; 59.69 |
45.36 35.36; 61.99 |
47.40 31.41; 56.31 |
p = 0.85 | 42.62 35.08; 59.90 |
47.40 31.41; 56.31 |
p = 0.69; U = 1114.0 |
45.76 33.72; 57.76 |
41.63 34.01; 59.69 |
p = 0.93; U = 1708.5 |
Platelet 5-HT concentration and platelet MAO-B activity are presented as median with 25th (Q1) and 75th (Q3) percentiles and compared in carriers of different genotypes (Kruskal-Wallis test) and alleles (Mann-Whitney test).