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Mechanisms of RNA therapeutics [5] (Via license: CC BY-NC-ND 4.0). anti-miRNA (A); miRNA mimics (B); block-miRNA agonists (C); RNA-induced silencing complex (RISC) (D,E1,E2); splicing process of mRNA (F); intracellular enzyme RNase H (G). Key: shRNA—short hairpin RNA; pri-miRNA—primary miRNA; pre-miRNA—precursor miRNA; TRBP—Tar RNA binding protein; AGOs—argonautes; Pol II—RNA polymerase II; siRISC—siRNA-induced silencing complex; miRISC—miRNA-induced silencing complex.
