Table 1.
Summary of the sociodemographic and clinical predictors used in developing ML models for the prediction of OTSCC recurrence.
| Variable | 5-Year (N = 14,995) | 10-Year (N = 7342) |
|---|---|---|
| No. (%) | No. (%) | |
| Mean Age, years (SD) | 58.4 (11.5) | 56.2 (11.5) |
| Sex | ||
| Male | 10,636 (72.0) | 4075 (67.7) |
| Female | 4129 (28.0) | 1943 (32.3) |
| Race | ||
| White | 13,261 (89.8) | 5991 (90.1) |
| Black | 706 (4.8) | 270 (4.1) |
| Asian | 798 (5.4) | 387 (5.8) |
| Marital Status | ||
| Single | 5056 (34.2) | 2040 (30.7) |
| Married | 9709 (65.8) | 4608 (69.3) |
| Number of Prior Tumors | ||
| 0 | 14,051 (95.2) | 6324 (95.1) |
| 1 | 496 (3.4) | 232 (3.5) |
| 2 | 161 (1.1) | 77 (1.2) |
| 3 | 46 (0.3) | 14 (0.2) |
| 4+ | 11 (0.1) | 1 (0.0) |
| Histology | ||
| Nonkeratinizing SCC with maturation | 11,468 (77.7) | 5276 (79.4) |
| Undifferentiated nonkeratinizing SCC | 86 (0.6) | 39 (1.0) |
| Differentiated nonkeratinizing SCC | 824 (5.6) | 288 (4.3) |
| Keratinizing SCC | 2286 (15.5) | 993 (15.0) |
| SCC NOS | 101 (0.7) | 52 (1.0) |
| Tumor Grade | ||
| Well-differentiated | 2262 (18.8) | 1067 (19.7) |
| Moderately differentiated | 5752 (47.8) | 2585 (47.6) |
| Poorly differentiated | 3896 (32.4) | 1710 (31.5) |
| Undifferentiated | 117 (1.0) | 64 (1.2) |
| T-Stage | ||
| T1 | 4443 (46.7) | 1594 (50.0) |
| T2 | 3274 (34.4) | 1109 (34.8) |
| T3 | 1013 (10.6) | 262 (8.2) |
| T4 | 784 (8.2) | 221 (6.9) |
| N-Stage | ||
| N0 | 5110 (45.5) | 1918 (48.3) |
| N1 | 1968 (17.5) | 764 (19.2) |
| N2 | 3847 (34.3) | 1187 (29.9) |
| N3 | 296 (2.6) | 102 (2.6) |
| M-Stage | ||
| M0 | 11,200 (99.3) | 3913 (99.2) |
| M1 | 75 (0.7) | 30 (0.8) |
| Surgery | ||
| Yes | 6125 (41.8) | 2506 (37.5) |
| No | 8519 (58.2) | 4185 (62.5) |
| Radiation | ||
| Yes | 8965 (60.7) | 3811 (57.3) |
| No | 5800 (39.3) | 2837 (42.7) |
| Chemotherapy | ||
| Yes | 6598 (44.7) | 2632 (39.6) |
| No | 8167 (55.3) | 4016 (60.4) |
SCC: Squamous Cell Carcinoma; NOS: Not Otherwise Specified; values are based on the number of cases.