Figure 10.

(a) Relative change in the number of cancer cells for HD, LD, NT and HDV with higher tumor vascular density (HDV) cases within the whole tumor. For each case, the solid line with different patterns is the mean of 10 replications, and the band displays the standard deviation; (b) the ratio of the number of cancer cells to immune cells within the ROI for HDV. The ratio varies between 2.6 and 0.2 over time. Bivariant classification of TME based on different spatial metrics and ratio of cancer cells to immune cells for HDV (green: compartmentalized; red: mixed; purple: cold). The following correspond to the compartmentalized immunoarchitecture: (c) lower mixing score; (d) lower average neighbor frequency; (e) higher Shannon’s entropy; (f) lower AUC of G-cross function.