Table 1.
Cancer to immune cell ratio and the change percentage of different spatial metrics within the ROI for R and NR cases. BT = before treatment; AT = after treatment. The percent changes in spatial metrics in R cases are higher than those in NR cases. In spite of Shannon’s entropy change, mixing score, average neighbor frequency and the AUC of the G-cross change for R cases are higher when the ratio of cancer cells to immune cells is lower. Change in Shannon’s entropy strongly depends on the cancer cell to immune cell ratio.
| Cell Ratio | Mixing Score | Average Neighbor Frequency | AUC of G-Cross Function | Shannon’s Entropy | |||
|---|---|---|---|---|---|---|---|
| BT | AT | Reduction (%) | Reduction (%) | Reduction (%) | Reduction (%) | Increase (%) | |
| R1 | 2.86 | 0.43 | 84.96 | 64.03 | 67.25 | 34.71 | 310.13 |
| R2 | 15.41 | 5.71 | 67.94 | 47.98 | 49.87 | 14.53 | 421.13 |
| R3 | 3.67 | 0.57 | 84.46 | 63.35 | 64.92 | 30.81 | 300.76 |
| R4 | 17.36 | 6.91 | 65.19 | 44.15 | 46.26 | 12.06 | 433.78 |
| R5 | 3.45 | 0.49 | 85.79 | 64.69 | 67.38 | 34.67 | 347.19 |
| NR1 | 3.19 | 2.84 | 10.97 | 2.82 | 3.28 | 2.91 | 4.24 |
| NR2 | 16.92 | 13.46 | 20.45 | 0.78 | 1.71 | 0.81 | 2.31 |
| NR3 | 19.64 | 15.41 | 21.53 | 0.0 | 0.86 | 0.0 | 0.93 |
| NR4 | 6.94 | 5.81 | 16.28 | 2.68 | 2.87 | 1.71 | 3.92 |
| NR5 | 18.49 | 14.56 | 21.25 | 0.68 | 1.21 | 0.67 | 2.15 |