Figure 1.

Heatmap of the mean expression of differentially expressed genes (DEGs) in at least one age group of both men and women. These genes were clustered for k-means = 11, and only clusters that formed gradients were displayed. The figure shows which genes become more expressed with age (cluster I) and less expressed with age (clusters A, B, and C). The functional enrichment of clusters A, B, and C indicates an overall decrease in genes involved in lipid metabolism, adipocyte differentiation, and energy expenditure processes, while the expression of genes involved in inflammatory and type I diabetes mellitus pathways increases. These genes are differentially expressed in at least one age group compared to the youngest group used as a reference. Row values are normalized by Z–score, so minimum and maximum values are row relative.