Figure 4.

Predicted connectome between visceral fat (a) and the liver (b) in males, including predicted visceral fat secreted ligands and their experimentally demonstrated liver receptors. Bar graph demonstrating enrichment scores from the Kyoto Encyclopedia of Genes and Genomes (c), as provided by Enrichr [28], revealed aging- and metabolic disease-related pathways (c). Only genes that are part of the “Longevity regulating”, “Cholesterol metabolism”, and “AMPK signaling” pathways are highlighted in green and yellow, respectively. Other genes appear in multiple other pathways and are displayed in grey without highlighting. Row values are normalized by Z-score, so minimum and maximum values are row relative. The geometric mean of all samples of transcripts per million (TPM) is displayed to reflect the absolute nonrelative expression of the gene in the tissue compared with other genes.