Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 10;15(10):2696. doi: 10.3390/cancers15102696

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

EpiSwitch Data Portal view of the EpiSwitch Marker located in CD274/PDCD1LG2 region imposed over the Integrative Genomic Viewer (IGV) (ref). Anchor sites brought into juxtaposition by chromosome long-range interactions of the EpiSwitch marker overlap with the listed SNPs and enhancers. Analysis of SNPs identified affected binding sites for transcription factors (TFs) such as ZEB1 [63]. GeneCards analysis of the enhancers identifies CD274 enhancer at the distal anchor site of the EpiSwitch marker. CD274 corresponds to PD-L1, and PDCD1LG2 to PD-L2 immune checkpoints.