Figure 10.

Horizontal transfer by EV, including exosomes, carry epigenetic information from primary sites to the secondary sites and the sites of systemic detection. Extracellular vehicles, including exosomes, carry representative loads of proteins, metabolites, and non-coding RNAs from primary sites, all of which could act as epigenetic regulatory factors for resetting 3D architecture of the selective genetic loci of the effector cells [73]. In early symptomatic systemic readouts, the cells of immunosurveillance were identified as a potential subject of primary 3D modulation, as in the case of early melanoma detection [39].