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. 2023 May 11;15(10):2718. doi: 10.3390/cancers15102718
OS overall survival
PD-1 programmed cell death protein-1
CTLA-4 cytotoxic T-lymphocyte-associated protein 4
LAG-3 lymphocyte activation gene-3
TIGIT T-cell immunoglobulin and ITIM domain
TIM-3 T-cell immunoglobulin- and mucin-domain-containing molecule-3
VISTA V-domain Immunoglobulin Suppressor of T-cell Activation
IDO1 indoleamine 2, 3-dioxygenase 1
IDO2 indoleamine 2, 3-dioxygenase 2
TDO tryptophan 2, 3-dioxygenase
B7-H3 B7 homolog 3 protein
HVEM herpesvirus entry mediator
BTLA B- and T-lymphocyte attenuator
MHC major histocompatibility complex
TCR T-cell receptor
TME tumor microenvironment
HLA human leukocyte antigen
DCR disease control rate
PFS progress-free survival
TIL tumor-infiltrating leukocytes
IFN-γ interferon gamma
TMB tumor mutational burden
mAb monoclonal antibody
TRAE treatment-related adverse event
RFS relapse-free survival
ORR objective response rate
mDOR median duration of response
DLT dose-limiting toxicity
NK cells natural killer cells
CAECAM1 carcinoembryonic antigen-related cell adhesion molecule 1
HMGB1 high-mobility-group box 1
ITIM immunoreceptor tyrosine-based inhibitory motif
ADCC antibody-dependent cellular cytotoxicity
MDSC myeloid-derived suppressor cells
CR complete response
APC antigen-presenting cells
CTL cytotoxic lymphocyte
DC dendritic cell
GPI glycosylphosphatidylinositol
miRNA microRNA