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Features and functions of Brother of the Regulator of imprinted sites (BORIS). (a) Representation of the domain distribution of BORIS and their percentage of identity with CTCF. (b) BORIS can alter chromatin loops by a competitive mechanism with CTCF and its inability to interact with the cohesin ring. Moreover, the recruitment of new protein partners by BORIS could explain the opposite behaviors of CTCF and BORIS. Created with BioRender.com (accessed on 23 April 2023).
