Table 1.
Known protein–protein interactions of BORIS. Proteins that were experimentally validated to interact with CTCF as well are labeled in red.
| Protein Types | Protein | Complex Function | Experimental Evidence | References |
|---|---|---|---|---|
| Chromatin-associated proteins |
PRMT7 | Arginine methylation to control imprinting. |
Immunoprecipitation. | [65] |
| CTCF | Unknown function in spermatogenesis. |
In situ proximity ligation assay. Immunoprecipitation |
[50,53] | |
| BAG6 SET1A |
Transcriptional activation of c-myc and BRCA1. |
Yeast two-hybrid assay | [57] | |
| POGZ SRCAP |
Unknown | Yeast two-hybrid assay | [57] | |
| TBP | Transcriptional activation of MAGE-A1. |
Pull down assay. | [66] | |
| SP1 | Transcriptional activation of NY-ESO-1. |
Immunoprecipitation. Pull down assay. |
[66,67] | |
| Transcription factors |
ELF2 | Unknown | Yeast two-hybrid assay | [57] |
| HCFC2, HCFC1 | ||||
| MGA | ||||
| TLK2 | ||||
| NFAT5 | ||||
| ZNF518 | ||||
| ATF7 | ||||
| MKL2 | ||||
| Ku70 | DNA damage repair. | Immunoprecipitation | [68] | |
| DNA Binding proteins |
UBF | rDNA transcriptional regulation. |
Immunoprecipitation. | [64] |
| CHD8 | ||||
| Signaling proteins |
CSTA FHL2 |
Unknown | Yeast two-hybrid assay |
[57] |