Table 3.
Summary of studies assessing accuracy of FL to CD endoscopic activity.
| Study (Name, Year) | Nation of Origin | CD Patients (n=) | Definition of Endoscopic Activity | Optimal FL Cut-off | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|---|---|
| D’Inca 2006 [31] | Italy | 31 | SES-CD ≤ 3/SES-CD > 3 | 0.007 optical density | 77% (57–89) |
80% (38–96) |
| Karczewski 2015 [34] | Poland | 55 | CDEIS ≤ 2/CDEIS > 2 | 25 µg/g | 75% (62–85) |
80% (38–96) |
| Langhorst 2006 [35] |
Germany | 43 | Authors score | 7.1 µg/mL | 81% (65–91) |
59% (32–82) |
| Sipponen 2008 [43] |
Finland | 116 | CDEIS ≤ 3/CDEIS > 3 | 10 µg/g | 66% (54–76) |
91% (77–96) |
Abbreviations: SES-CD: simplified endoscopy score for Crohn’s disease, CDEIS: Crohn’s disease endoscopic index of severity.