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. 2023 May 19;11(5):1480. doi: 10.3390/biomedicines11051480

Figure 2.

Figure 2

Inhibitory effect of TRPM4 blocking antibody M4P. (A) Exemplary current-voltage relationships of TRPM4 channel under the treatment of 20 µg/mL control IgG or 20 µg/mL M4P. Ramp protocols were applied from − 100 to + 100 mV with a holding potential at 0 mV. (B) Summary of current density at −100 and +100 mV. M4P: n = 12 cells; control IgG: n = 15 cells. (C) Exemplary current–voltage relationships of TRPM4 channel after 7-min ATP depletion. (D) Summary of current density under 7-min ATP depletion at −100 and +100 mV. M4P: n = 9 cells; control IgG: n = 12 cells. Statistical analysis was performed by student’s t-test. * p < 0.05, ** p < 0.01. The numerical data supporting the graphs can be found in Supplementary Table S2.