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. 2023 May 11;15(10):2720. doi: 10.3390/cancers15102720

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PLA2R1 suppresses DTC metastasis through the ITGB1/FAK axis. (A,B) Effects of PLA2R1 on the p-FAK, EMT protein, and apoptotic protein levels in thyroid cancer cell lines 8505c and FTC133, as determined by Western blotting. (C) FN1 (rhFN1) antagonizes the effects of PLA2R1 on ITGB1 expression and FAK phosphorylation in thyroid cancer cell lines 8505c and FTC133; ns, not Significant; * vs. Vector p < 0.05; ** vs. Vector p < 0.01; *** vs. Vector p < 0.001; # vs. rhFN1 p < 0.05; ## vs. rhFN1 p < 0.01; ### vs. rhFN1 p < 0.001. The uncropped blots are shown in File S1.