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. 2023 May 5;11(5):1365. doi: 10.3390/biomedicines11051365

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolic pathways regulating lipid metabolism in PBTs, and specific molecular signatures related to plasma membrane receptors, nuclear receptors, and the metabolism of specific lipid subtypes. Arrows indicate good (↑) or bad (↓) prognosis associated with the high expression of ACSL4, GALC, FABP5, FADS1, and SMS2. CER: ceramide FFA: free fatty acids, LDs: lipid droplets, LPA: lysophosphatidic acid, PI3K: phosphatidyl inositol kinases, PLs: phospholipids, PLC: phospholipase C, SM sphingomyelin, S1P: sphingosine phosphate, UPR: unfolded protein response.