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Topological arrangement of prokaryotic and eukaryotic TMEM175 channels. (A) Schematic diagram of the prokaryotic TMEM175 channel structures. (B) Structural model of CmTMEM175 (PDB code: 5VRE). (C) Schematic diagram of the eukaryotic TMEM175 channel structures. (D) Structural model of hTMEM175 (PDB code: 6WC9, open state TMEM175 in KCl).
