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. 2023 May 9;15(10):2664. doi: 10.3390/cancers15102664

Figure 1.

Figure 1

HER2 homogenous and heterogeneous staining patterns (intratumoral heterogeneity (ITH)) using HER2 gene protein assay (GPA) with simultaneous HER2 in situ hybridization and immunohistochemistry on breast cancer tissue sections. (A) Homogeneous staining with classic HER2 positive tumor cells with both amplified HER2 gene and overexpressed HER2 protein. (B) HER2 genetic intratumoral heterogeneity with classic HER2 positive tumor cells and HER2 negative tumor cells. (C) HER2 non-genetic intratumoral heterogeneity with a mixture of classic HER2 positive tumor cells and non-classic HER2 positive tumor cells harboring amplified HER2 gene, but no overexpression of HER2 protein.