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. Author manuscript; available in PMC: 2024 Mar 30.
Published in final edited form as: Cell. 2023 Mar 22;186(7):1382–1397.e21. doi: 10.1016/j.cell.2023.02.022

Figure 1. CCHa1 and its receptor suppress arousability from sleep.

Figure 1.

(A) Schematized screen for genes that regulate arousability from sleep, using weak (top) and strong (bottom) mechanical vibrations. Hyper- and hypo-arousable phenotypes exceeding two standard deviations from the mean are highlighted (data in Tables S1 and S2). Data were normalized for spontaneous arousals from sleep, and negative values are seen when spontaneous arousals are more frequent than arousals after stimulation. (B) Percent of flies awoken by weak mechanical vibrations when RNAis against CCHa1 or its receptor are expressed using elav-Gal4. (C) Mutants for CCHa1 or its receptor. In B and C grays represent parental controls. Error bars, mean and S.E.M. Genotypes, sample sizes and statistical analyses, Table S3. See also Figure S1. In all figures * p<0.05, ** p<0.01, *** p<0.001.