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. Author manuscript; available in PMC: 2024 Mar 30.
Published in final edited form as: Cell. 2023 Mar 22;186(7):1382–1397.e21. doi: 10.1016/j.cell.2023.02.022

Figure 2. CCHa1 peptide signals from the gut to suppress arousability.

Figure 2.

(A) Antibody staining against CCHa1 in the nervous system and the posterior midgut, in control animals (UAS-CCHa1-RNAi) and animals in which CCHa1 is depleted using elav-Gal4 (elav>CCHa1-RNAi). (B) CCHa1 staining, and arousability from sleep, when CCHa1 is conditionally depleted using pros-Gal4 (prosts>CCHa1-RNAi). In A and B, scale bars: 100 μm. (C) Arousability from sleep when enteroendocrine cells are activated (yellow), or when they are activated and simultaneously depleted of CCHa1 (pink). UAS-GFP was included to control for UAS number. (D) Schematic. Error bars, mean and S.E.M. Genotypes, sample sizes and statistical analyses, Table S3. See also Figure S2.