| Interleukin-6 |
Stimulating acute phase protein synthesis, neutrophils production, fever mediation, B-cell growth stimulation |
| Interleukin-1α |
Part of epithelial barrier, epithelium integrity preservation |
| Interleukin-1β |
Modulating inflammatory response, pyrogen, pain hypersensitivity, cell proliferation |
| Tumor Necrosis Factor α |
Immune cells modulation, cell signaling, inflammation regulation, response to bacterial lipopolysaccharide |
| Interleukin-8 |
Neutrophil chemotaxis, phagocytosis stimulation |
| Interleukin-17 |
Recruitment of immune cells (mainly neutrophils and monocytes) via chemokines, promotes inflammatory responses of IL-1β and TNF-α |
| Interleukin-10 |
Anti-inflammatory agent, blocks NFkB activity resulting in decrease in osteoclasts formation, TNF-α regulation |
| MMP-8 |
Catalyzes the degradation of collagen type III and I |
| MMP-2 |
Collagen type IV degradation, cell-cell clustering |
| MMP-9 |
Collagen type IV and V degradation, cooperation with MMP-2 in ECM remodeling |
| MMP-7 |
Gelatin, fibronectin and proteoglycan degradation, probably plays role in wound healing |
| MMP-13 |
Collagen type I, II and III degradation, tissue remodeling |
| TIMP-1 |
MMPs inhibition, cell proliferation promotion |
| TIMP-2 |
MMPs inhibition, complements TIMP-1 in maintaining tissues hemostasis |
| RANKL |
Bone remodeling and regeneration control, cell proliferation, with RANK binding promotes osteoclasts formation and maturation |
| Osteoprotegrin |
Suppression of osteoclasts formation by competitive binding to RANK |
