Figure 1.

Demonstration of NC-NHA and NC-NCVS gelling systems that undergo physical gelation via thermo-responsive poly(NIPAAm) segment and chemical gelation through an addition reaction between thiols and vinyls. (A–F) Images of live/dead assay on mouse fibroblasts under (A–C) bright field and (D–F) fluorescent for control, NC-NCVS, and NC-NHA systems. (G–L) Various stages of the in vitro catheter delivery of the NC-NHA and NC-NCVS hydrogel in an aneurysm glass model. (G,J) Balloon inflated and hydrogel injected in aneurysm sac, (H,K) balloon taken down, and (I,L) flow, in direction of arrow, resumed to observe embolization results of the gelling systems.