Table 3.
Inhibition zone diameter of clotrimazole-loaded borneol-based ISG and related formulations against S. aureus, E. coli, C. albicans, C. krusei, C. lusitaniae, and C. tropicalis (n = 3).
| Microbes | Inhibition Zone Diameter (Mean ± SD) (mm) | |||||||
|---|---|---|---|---|---|---|---|---|
| NMP | CN | ZN | ZCN | 20BZCN | 30BZCN | 40BZCN | 50BZCN | |
|
S. aureus ATCC 6538 |
10.67 ± 1.53 | 14.17 ± 1.04 | 21.33 ± 1.53 | 20.00 ± 1.00 | 20.33 ± 0.58 | 17.00 ± 1.00 | 16.00 ± 1.00 | 13.83 ± 1.26 |
|
E. coli ATCC 25922 |
17.67 ± 1.53 | 19.00 ± 1.00 | 18.00 ± 1.00 | 17.00 ± 1.00 | 14.00 ± 1.00 | 12.33 ± 1.53 | 11.00 ± 1.00 | 8.17 ± 0.29 |
|
C. albicans ATCC 17110 |
28.33 ± 1.53 | 30.33 ± 0.58 | 39.33 ± 0.58 | 39.00 ± 1.00 | 43.67 ± 1.15 | 42.67 ± 0.58 a | 42.33 ± 0.58 a | 42.67 ± 0.58 a |
|
C. krusei TISTR 5259 |
14.33 ± 1.53 | 14.00 ± 2.00 | 37.00 ± 2.00 b | 32.00 ± 1.00 | 38.67 ± 0.58 | 36.33 ± 1.53 b | 34.67 ± 1.15 | 31.00 ± 1.73 |
|
C. lusitaniae TISTR 5156 |
30.00 ± 1.00 | 30.67 ± 0.58 | 38.33 ± 1.15 c | 38.33 ± 0.58 c | 39.33 ± 1.53 | 37.00 ± 1.00 c | 35.33 ± 0.58 | 33.33 ± 0.58 |
|
C. tropicalis TISTR 5306 |
27.67 ± 0.58 | 29.33 ± 0.58 | 36.33 ± 0.58 | 37.00 ± 1.00 | 40.67 ± 1.15 | 39.33 ± 0.58 d | 36.33 ± 0.58 | 35.00 ± 1.00 |
The superscripts a, b, c, and d represent a significant difference (p < 0.05) compared with 20BZCN.