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. 2023 May 12;10:1081087. doi: 10.3389/fmed.2023.1081087

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Copyright © 2023 Soman, Nelson, Cerono, Goldman, Baranzini and Brown.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD patient specific networks from SPOKE (A) corresponds to a patient correctly diagnosed by both clinician and SPOKE model. (B) corresponds to a patient correctly diagnosed only by SPOKE model. Triangle shaped nodes represent clinical concepts present in patient’s EHR chart and hence the entry points to SPOKE. Circle shaped nodes are the non-entry points. Nodes are connected by edges whose names are shown in the figure. To reduce the complexity of the network (B), certain nodes and edges are grayed out based on manual inspection. Legend shows the color code for each node type in the network.