Table 2.
Top results from the Cross-Ancestry meta-analysis in METASOFT
| Chr | SNPID | Gene | A1 | Pheno_Eur | Pheno_AA | Cross_Beta | Cross_P | AA_Beta | AA_P | Eur_Beta | Eur_P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 19 | rs507766 | FUT2 | T | CUD,PAU | CUD,AUD | −0.009 | 3.47E-19 | 0.007 | 0.914 | −0.004 | 2.66E-04 |
| 16 | rs9928094 | FTO | A | PTU,OUD,PAU | OUD,AUD | 0.006 | 6.50E-32 | 0.011 | 0.321 | 0.006 | 1.63E-11 |
| 2 | rs472140 | NA | C | PTU,PAU | CUD,PTU | −0.007 | 3.79E-43 | −0.02 | 0.722 | −0.007 | 7.66E-13 |
| 4 | rs6846266 | NA | A | PTU,PAU | OUD,AUD | −0.005 | 6.05E-23 | −0.011 | 0.317 | −0.005 | 3.61E-06 |
| 3 | rs62250713 | CADM2 | G | CUD,PAU | CUD,AUD | 0.009 | 1.00E-18 | 0.018 | 0.268 | 0.009 | 6.97E-11 |
| 1 | rs784601 | NA | G | CUD,PTU,PAU | CUD,PTU | −0.004 | 3.57E-15 | −0.014 | 0.519 | −0.004 | 2.47E-05 |
| 7 | rs4727799 | FOXP2 | C | CUD,PTU | PTU,OUD | −0.004 | 3.90E-15 | −0.024 | 0.752 | −0.004 | 2.74E-06 |
| 22 | rs6002381 | NA | T | CUD,PTU,PAU | PTU,AUD | −0.007 | 5.23E-12 | −0.022 | 0.551 | −0.007 | 1.13E-06 |
| 12 | rs1497253 | IRAG2 | A | CUD,PTU,OUD,PAU | CUD,PTU,AUD | −0.004 | 4.01E-15 | 0.007 | 0.914 | −0.004 | 2.66E-04 |
| 14 | rs7147171 | PP1R13B | G | PTU,PAU | PTU,OUD,AUD | −0.007 | 3.71E-12 | −0.01 | 0.37 | −0.007 | 3.09E-10 |
| 15 | rs35175834 | SEMA6D | G | CUD,PTU,PAU | CUD,PTU,OUD,AUD | −0.007 | 5.84E-12 | 0.007 | 0.959 | −0.007 | 3.51E-07 |
| 20 | rs293553 | C20orf112 | A | PTU,OUD | PTU,OUD | −0.009 | 2.03E-09 | −0.018 | 0.24 | −0.009 | 1.43E-07 |
| 9 | rs7033815 | SCAI | G | PTU,OUD | CUD,OUD,AUD | 0.006 | 2.71E-09 | 0.018 | 0.171 | 0.006 | 2.83E-06 |
| 17 | rs587880 | FBXL20 | G | OUD,PAU | OUD,AUD | −0.009 | 1.07E-09 | −0.014 | 0.119 | −0.009 | 1.36E-05 |
| 18 | rs4996482 | RP11–397A1 6.1 | C | CUD,PTU,OUD | CUD,OUT | 0.006 | 3.54E-09 | 0.028 | 0.006 | 0.261 | 4.18E-07 |
| 5 | rs7708715 | TMEM161B-AS1,CTC-498M16.2 | C | CUD,PTU | CUD,OUD,AUD | 0.003 | 3.59E-09 | 0.013 | 0.34 | 0.003 | 6.16E-05 |
| 8 | rs2321459 | LEKR1 | T | PTU,PAU | PTU,OUD | −0.006 | 3.68E-09 | −0.009 | 0.974 | −0.006 | 4.51E-05 |
| 6 | rs62394558 | NA | G | CUD,PTU | CUD,OUD | −0.003 | 3.89E-09 | −0.02 | 0.962 | −0.003 | 8.00E-03 |
| 1* | rs1937439 | PDE4B | A | CUD,PTU,PAU | CUD,AUD | 0.007 | 5.18E-12 | 0.025 | 0.173 | 0.007 | 4.54e-10 |
| 4* | rs10031172 | BANK1 | T | CUD,OUD,PAU | Tob,AUD | −0.006 | 1.93E-09 | −0.014 | 0.090 | −0.006 | 8.03e-05 |
Note. Chr = Chromosome, SNPID = snp rsID, Gene is closest gene, A1 is effect allele. Pheno_AA lists the phenotypes associated with the SNP in the African Ancestry Sample GWAS. Pheno_Eur lists the phenotypes associated with the SNP in the European sample, Cross_Beta is the cross-ancestry Beta from the METASOFT random effects meta-analysis. Cross_P is the P from the P-value of the cross ancestry meta-analysis. AA_Beta is the transformation of the OR from ASSET when run in the African American Sample. AA_P is the pvalue from ASSET. Eur_Beta is the transformation of the Odds Ratio (to a Beta) from ASSET when run in the European sample. Eur_P is the P-value from ASSET. Significance is set at Bonferroni corrected genome-wide significance in a two-sided test (P < 5e-8).