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Rhein induces S-phase cell cycle arrest of OC cells. (A) The effects of rhein on cell cycle distribution were quantitated by flow cytometry. (B) Bar graph representing the quantified values of cells in different phases. (C) The protein expressions of cyclin A1, CDK2, and cyclin E1 were determined using Western blotting. * p < 0.05; ** p < 0.01; *** p < 0.001.
