Table 2.

List of malign and benign features of hereditary cancer syndromes. HCS = hereditary cancer syndrome. Blue boxes identify a typical features of that syndrome; black box identify features that are commonly associated with that syndrome; gray box identify features that rarely associated with that syndromes or the association is weakly supported by the literature. The readers can find the benign/malign phenotype of a patient/family in the table to better hypothesize the underlying HCS. Sources: GeneReview, UptoDate, Omim, EviQ Genetics.

	HPPS	CNC	NF1	NF2	SCHW	MEN 1	MEN2A	MEN2B	FMTC	MEN4	HPT- JT	PC	HOXB13	NBN	NBS	VHLS	HPRC	HLRCC	TSC	BHD	LF	BSyn	fGIST	BRCA1/2	CHEK2	PALB2	RAD51C	RAD51D	ATM (Heterozygosis)	AT	STK11	BARD1	BRIP1	FANCONI ANEMIA	FAMM	NBCC	XP	BAP1	Shelterin	TERT	MC1R	MITF	DICER1	LS	RPS20	FAP	AFAP	GAPPS	PPAP	MAP	NTHL1	MSH3	MLH3	JPS	HMPS	RNF43	CS	HDGC	HP	HE	EGFR
HCS-associated cancers
Esophagus/Stomach
Small bowel
Colon/Rectum
Anus
Pancreas
Liver
Biliary tract
Breast
Ovary
Endometrium
Cervix
Vulva/Vagina
Prostate
Testicles
Penis
Kidney
Bladder/Urothelial
Melanoma
Skin (non-melanoma)
Lung
Mesothelium
Head & neck
Sarcoma
GIST
Neuroendocrine
Pheocromocytoma/Paraganglioma
Adrenal
Thyroid
Parathyroid
Nervous system
Lymphoma
Leukemia
Thymus
Parotid
Endolymphatic sac tumors
Choriocarcinoma
HCS-associated benign features
Eyes
Nose
Mouth
Esophagus/Stomach
Small bowel
Colon/Rectum
Biliary tract
Pancreas
Kidney
Bladder/Urothelium
Breast
Testicular
Gynecological
Skin/Soft tissue
Lung
Skeleton
Adrenal
Thyroid
Parathyroid adenoma
Pituitary gland
Nervous system
Cognitive alterations
Heart
Facies/Habitus
Blood
Blood vessels
Thymus
Parotid
Liver
Immune system
Endocrine dysfunction