Table 4.

A summary of different types of silk fibroin hydrogels used in cornea, dental and Tympanic Membrane.

	Material(s)	Experimental Mode	Synthesis Method	Function	Ref.
Cornea	SF, PVA, nano-Hydroxyapatite, Dimethyl sulfoxide (DMSO), Genipin (GP)	In vitro	Chemical cross-linking agents	HCFs proliferate in composite hydrogel pores	[221]
	SF, PA, N,N′-MBAAm(cross-linker)	In vitro	Chemical cross-linking agents	Promote keratinocyte migration	[223]
	Acetone Optima, SF solution	In vitro	Chemical cross-linking agents	Provide a place for HCECs to adhere and proliferate	[225]
	SF solution, GelMA, Irgacure 2959(photoinitiator)	In vitro	Photocrosslinking	SF improved the mechanical stability and adhesion of the composite hydrogel and reduced the degradation rate	[14]
	Glycidyl methacrylate, SF solution	In vitro	Photocrosslinking	Effectively inhibit bacterial growth by loading antibiotics	[236]
	SF, flavin mononucleotide (FMN)	In vitro	Photocrosslinking	Change the optical thickness of the cornea	[241]
Dental	RSF, carbamide	In vitro	Shear force	Support the proliferation of hDPSCs	[263]
	SF, Riboflavin (photoinitiator)	In vitro	Photocrosslinking	Support the proliferation of hDPSCs	[264]
	SF	In vitro	Self-assembly	Supporting stem cell proliferation of human deciduous teeth	[265]
	SF, HA, Irgacure 2959(photoinitiator)	In vitro	Photocrosslinking	Control the differentiation of hDPSCs and promote the formation of new tissues	[266]
	SF, Td drug, Mel crystalline, Type A porcine skin gelatin, Irgacure 2959, methacrylic anhydride, High methoxyl Pectin, Thiogylcolic acid	In vitro	Electric field	Promote hDPSCs proliferation and odontogenic differentiation	[274]
Tympanic Membrane	SF scaffolds (SFS)	In vitro		Complete closure of the piercing site and early recovery of hearing	[286]
	Polycaprolactone (PCL), SF, human umbilical cord serum (hUCS)	In vitro		Effectively heals perforated tympanic membranes and improves hearing	[288]