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Roles of 17β-HSD10 in neurosteroid metabolism. 17β-HSD10 (red) is localized in the mitochondria and catalyzes the oxidation of allopregnanolone (ALLOP, blue), a positive modulator of GABAA receptors that potentiates GABA to increase the opening of Cl- channels. The postsynaptic GABAA receptor was magnified and is shown at the right side. ―• indicates the binding sites of individual modulators on the GABAA receptor [3]. Reproduced from Figure 2 of Ref. [3].
