PPIGCF: A Protein–Protein Interaction-Based Gene Correlation Filter for Optimal Gene Selection

. 2023 May 10;14(5):1063. doi: 10.3390/genes14051063

Algorithm 3. Gene correlation filter (GCF)

Input:

R D_{1}

Output: Strongly correlated genes in the PPI network.

Begin:

Compute Pearson’s correlation matrix (

r_{i j}

) using Equation (2).

for each i = 1 to n do:

for each j = 1 to n do:

r_{i j}

> 0 then:

Compute

R_{i j}^{2}

using Equation (3).

R_{i j} \to 0

then:

L L s c o r e_{i} (g_{i}, g_{j}) \to 1 & & S e m s i m (g_{i}, g_{j}) \to 1

then:

R D_{2} \cup R_{i j}

;

End if.

else:

Eliminate (

g_{i}, g_{j}

);

End if.

End for.

return

R D_{2}

;

End.