Table 6.

KEGG pathways mapped to lung cancer genes obtained from FRD.

KEGG Pathway Name	Fold Enrichment Score	Significance
Complement and Coagulation Cascade	31.93	The complement system serves as the main component of the immunity system, whereas the coagulation system is the pillar supporting hemostasis. Interaction between these two cascades is often proposed but has not yet been established via clinical trials [59].
Carbon Metabolism	23.32	Altered carbon metabolism plays a critical role in rapid and unregulated proliferation. One-carbon metabolism plays a significant role in DNA synthesis. Therefore, its role in cancer prognosis is essential [60].
Fluid Shear Stress and Atherosclerosis	19.43	Shear stress caused by liquid flow plays a significant role in cancer development. It affects tumor progression by actively participating in tumor cell proliferation, apoptosis, invasion, and metastasis [61].