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. 2023 May 10;14(5):1063. doi: 10.3390/genes14051063

Table 7.

KEGG pathways mapped to DLBCL cancer genes obtained from FRD.

KEGG Pathway Name Fold Enrichment Score Significance
Pentose and Glucuronate Interconversions 67.05 This pathway forms the basis of other critical pathways, such as the carbohydrate metabolic pathway. It is involved in the interconversion of monosaccharide pentose and glucuronate, the salts or esters of glucuronic acid. This pathway includes 28 different members, according to the KEGG database. The pentose and glucuronate interconversion pathways play a significant role in many biosynthetic processes. It can be said that aberrant pentose and glucuronate interconversions can lead to various diseases, such as familial tumoral calcinosis [62].
Aldosterone-regulated Sodium Reabsorption 61.61 The epithelial sodium channelplays a significant role in cancer cell proliferation [63].
N-Glycan Biosynthesis 45.59 Glycosylation induces significant functional changes in various glycoproteins, including cell surface receptors, adhesion molecules, etc. These changes confer unique characteristics and phenotypes associated with cancer cells [64].
P-53 Signaling Pathway 31.23 Activated by various stresses, genotoxic damage, etc., the P-53 signaling pathway can arrest the growth of cancer cells. Therefore, it is suitable for cancer detection and feature extraction analysis from biological datasets [65].