Table 2.
Table of top 10 downregulated and top 10 upregulated transcripts (by p value) for genetically identical scoliotic vs. non-scoliotic 6 wpf kif7co63/co63 zebrafish (D. rerio). Corresponding zebrafish genes and predicted human gene orthologs are provided (via ZFIN). p adjusted indicates values after multiple testing correction.
| Fold Change | Log2 Fold Change | p Value | p Adjusted | Gene Name | Predicted Human Ortholog |
|---|---|---|---|---|---|
| 0.0494 | −4.34 | 8.55 × 10−113 | 5.20 × 10−109 | ces2 | CES2 |
| 0.0093 | −6.75 | 1.12 × 10−81 | 5.44 × 10−78 | CABZ01032488.1 | Unknown |
| 0.0317 | −4.98 | 8.66 × 10−58 | 2.34 × 10−54 | ttc38 | TTC38 |
| 0.0068 | −7.19 | 8.69 × 10−39 | 1.41 × 10−35 | ces3 | CES3 |
| 0.0583 | −4.10 | 1.23 × 10−38 | 1.88 × 10−35 | si:dkey-167k11.5 | CCDC134 |
| 0.1780 | −2.49 | 3.19 × 10−30 | 3.89 × 10−27 | pip4p1a | PIP4P1 |
| 0.3392 | −1.56 | 7.42 × 10−28 | 7.53 × 10−25 | ctsd | CTSD |
| 0.2588 | −1.95 | 2.89 × 10−24 | 2.43 × 10−21 | si:ch211-195h23.3 | CARD8 |
| 0.0003 | −11.76 | 1.63 × 10−22 | 1.24 × 10−19 | si:dkeyp-73d8.9 | Unknown |
| 0.2253 | −2.15 | 4.62 × 10−22 | 3.31 × 10−19 | lig1 | LIG1 |
| 174.85 | +7.45 | 1.14 × 10−293 | 2.79 × 10−289 | krt4 | KRT8 |
| 107.63 | +6.75 | 1.13 × 10−163 | 1.37 × 10−159 | zgc:158846 (krtt2c6) | KRT7,8,9 |
| 131.60 | +7.04 | 1.00 × 10−150 | 8.13 × 10−147 | zgc:77517 (krtt1c6) | KRT18 |
| 31.34 | +4.97 | 9.44 × 10−76 | 3.83 × 10−72 | os9 | OS9 |
| 23.59 | +4.56 | 2.27 × 10−68 | 7.90 × 10−65 | si:ch73-308m11.1 | GIMAP8 |
| 51.27 | +5.68 | 9.23 × 10−66 | 2.81 × 10−62 | si:ch211-11p18.6 | Unknown |
| 19.29 | +4.27 | 3.63 × 10−54 | 8.84 × 10−51 | CR774195.1 | Unknown |
| 5.13 | +2.36 | 2.49 × 10−44 | 5.52 × 10−41 | tmem97 | TMEM97 |
| 280.14 | +8.13 | 1.12 × 10−41 | 2.27 × 10−38 | myl6 | MYL6 |
| 15.14 | +3.92 | 4.14 × 10−41 | 7.77 × 10−38 | BX322618.1 | Unknown |