Table 2.
The gene ontology (GO) functional category analysis of genes differentially expressed in murine B16 melanoma cells in response to 48 h of GANT61 or control treatment.
| Term | Gene Count | p-Value |
|---|---|---|
| G protein-coupled receptor signaling pathway | 101 | 0.000051 |
| Defense response to virus | 24 | 0.000061 |
| Negative regulation of viral genome replication | 10 | 0.00019 |
| Sensory perception of smell | 72 | 0.00025 |
| Spermatogenesis | 38 | 0.00036 |
| Protein kinase B signaling | 8 | 0.0024 |
| Response to virus | 11 | 0.0038 |
| Bicarbonate transport | 5 | 0.0052 |
| Response to type I interferon | 4 | 0.0086 |
| Limb bud formation | 4 | 0.0086 |
| Regulation of viral entry into host cell | 5 | 0.0093 |
| Cellular response to interferon-alpha | 5 | 0.0093 |
DAVID v6.8 functional annotation bioinformatics microarray analysis was used to obtain the GO biological process functional categories. Only GO terms for categories that show statistically significantly differences in the number of genes (compared with control) are shown (thresholds: count ≧ 2, p < 0.01).