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A framework model for analyses of the role of mutations in adaptation to SN-38. Schematic representation for (a) normal reference genome allele, (b) alleles found in parental SCC1 clone, (c) de novo mutations in MSC clones after NHEJ repair, (d) allele change upon loss of heterozygosity after HR repair (loss of heterozygosity herein is referred to as the change of mutated heterozygous alleles reversed to homozygous reference in selected variants).
