Figure 2.

Implications for healthy ageing related to gut microbiota. GM is capable of influencing healthy aging as well as inducing age-related diseases. On the one hand (A) Prevotella species have the faculty to induce dendritic cell activity and the release of proinflammatory cytokines (IL23, IL-6 and IL-1). However, there are bacterial strains associated with longevity (B), including: A. muciniphila, which de-creases activation of CD80+ and CD273+ B cells in Peyer’s patches, accompanied by attenuation of immu-ne-associated processes. They modulate the decrease of the proinflammatory profile and oxidative stress through the positive regulation of antioxidant enzyme.