Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Structural similarity of the chalcone and the chalcone amide scaffolds, and GRL0617 as a well-known inhibitor of SARS-CoV PLpro. (B) The structure of the predicted selective ligands CHA-11, CHA-37, and CHA-44 toward SARS-CoV-2 PLpro. (C) Structure of the fluorophenyl containing chalcones CHA-177 and CHA-7 and the previously reported compounds L and M. Asterisk in the structure of chalcone indicates the location of the bioisosteric replacement.
