Table 4.
ACE-I/D genotype associated training effects on perfusion-dependent muscle metabolism and cardiac function at rest. Mean ± SE of values over all (n = 9), carriers (n = 7) and non-carriers (n = 2) of the ACE I-allele. The p-value tested a potential difference between I-allele carrier and non-carrier (repeated-measures ANOVA for the training and ACE-allele factors) for metabolic parameters of muscle and cardiac function at rest. Bold underlined values indicate those effects being considered relevant at a threshold of 5%.
| All | Non-Carriers | I-Allele Carriers | p-Value | |
|---|---|---|---|---|
| cardiac output [L min−1] |
4.7 ± 0.4 | 7.3 ± 0.5 | 4.0 ± 0.4 | 0.013 |
| heart rate [beat min−1] |
78.3 ± 2.7 | 95.0 ± 0.0 | 73.6 ± 3.5 | 0.016 |
| systolic blood pressure [mmHg] |
118.8 ± 7.0 | 125.0 ± 18.0 | 117.0 ± 3.8 | 0.482 |
| diastolic blood pressure [mmHg] |
75.4 ± 5.3 | 74.0 ± 8.0 | 75.9 ± 4.6 | 0.853 |
| glucose [mM] |
5.3 ± 0.3 | 6.1 ± 0.5 | 5.1 ± 0.3 | 0.132 |
| lactate [mM] |
0.8 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | 0.299 |
| SmO2 at rest VAS [%] |
57.2 ± 11.0 | 53.0 ± 2.8 | 58.4 ± 13.3 | 0.349 |
| SmO2 at rest GAS [%] |
52.0 ± 5.6 | 43.5 ± 2.1 | 54.4 ± 6.7 | 0.009 |
| tHB at rest VAS [mg mL−1 s] |
12.7 ± 0.4 | 12.7 ± 0.4 | 12.8 ± 0.4 | 0.887 |
| tHB at rest GAS [mg mL−1 s] |
12.6 ± 0.3 | 12.5 ± 0.1 | 12.7 ± 0.4 | 0.241 |