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. 2023 May 16;24(10):8861. doi: 10.3390/ijms24108861

Figure 1.

Figure 1

MITF mRNA expression is negatively correlated with macroscopic tumour pigmentation in a set of 64 enucleated UM. Furthermore, MITF expression is significantly lower in monosomy 3 than in disomy 3 UM. (a): MITF mRNA expression as determined in an Illumina microarray in 64 cases from the Leiden cohort, divided into tumours with macroscopically light or dark pigmentations (Mann–Whitney U test). (b): Distribution of MITF mRNA expression in UMs according to chromosome 3 status plus pigmentation levels in the Leiden 64 UM case cohort, Mann–Whitney U test. (c): Distribution of MITF mRNA expression in UMs according to chromosome 3 and 8q status in the Leiden 64 UM case cohort, Mann–Whitney U test.