Table 1.
Distribution of MITF mRNA expression in UM with different clinicopathological features in 64 UM from the Leiden cohort. MITF mRNA expression as determined in an Illumina microarray. Significant p values are shown in bold.
| Median (Min-Max) | |||
|---|---|---|---|
| Feature | Nr | MITF Expression | p Value |
| Gender | |||
| Male | 33 | 10.44 (9.4–11.3) | 0.60 a |
| Female | 31 | 10.48 (9.6–11.6) | |
| Iris colour e | |||
| Light | 29 | 10.52 (9.6–11.4) | 0.28 a |
| Dark | 8 | 10.25 (10.0–11.1) | |
| Tumour pigmentation f | |||
| Light | 43 | 10.59 (9.4–12.0) | 0.003 a |
| Dark | 20 | 10.21 (9.6–10.8) | |
| Cell type | |||
| Spindle cell | 22 | 10.50 (9.6–11.5) | 0.76 a |
| Epithelioid-mixed cell | 42 | 10.41 (9.4–11.6) | |
| Ciliary body involvement | |||
| No | 39 | 10.48 (9.4–11.6) | 0.64 a |
| Yes | 25 | 10.38 (9.6–11.1) | |
| TNM stage | |||
| I-IIB | 36 | 10.50 (9.6–11.6) | 0.28 a |
| IIIA-IIIC | 26 | 10.35 (9.4–11.1) | |
| Chromosome 3 status | |||
| Disomy | 24 | 10.77 (10.1–11.6) | <0.001 a |
| Monosomy | 40 | 10.27 (9.4–11.0) | |
| Chromosome 8q status | |||
| Normal | 13 | 10.84 (9.7–11.4) | 0.02 b |
| Gain | 23 | 10.48 (9.6–11.6) | |
| Amplification | 27 | 10.32 (9.4–11.0) | |
| Chromosome 6p status | |||
| Normal | 43 | 10.35 (9.6–11.6) | 0.049 a |
| Gain | 21 | 10.53 (9.4–11.5) | |
| BAP1 expression (IHC) e | |||
| BAP1 positive | 25 | 10.53 (9.6–11.4) | 0.002 a |
| BAP1 negative | 31 | 10.35 (9.4–11.5) | |
| Age at enucleation | −0.063 c | 0.62 d | |
| Largest Basal Diameter | −0.168 c | 0.18 d | |
| Thickness | −0.122 c | 0.34 d |
a: Mann–Whitney U test; b: Kruskal–Wallis test; c: Spearman’s correlation coefficient; d: Spearman’s correlation; e: Iris colour and BAP1 IHC were not available for all cases; f: light pigmentation includes unpigmented and lightly pigmented UM, dark pigmentation includes moderately and heavily pigmented UM. IHC = Immunohistochemistry. TNM = Tumour Node Metastasis.