Table 1.
Literature review presenting in total 6 related studies and pointing out different study designs and results.
| Samples | Dataset (Cases) | Deliverables | Reference |
|---|---|---|---|
| OSCC | H&E-stained whole-slide images (training set n = 20, validation set n = 60) | Simultaneous segmentation of microvessels and nerves | Neural Comput &Applic 32, 9915–9928 (2020) [16] |
| HNSCC | H&E-stained whole-slide images (n = 334) | Segmentation of nerves and PNI | PMID: 36496513 [17] |
| OSCC | H&E-stained whole-slide images (training set = 80, validation set = 10) | PNI classifier | PMID: 36353548 [18] |
| HNSCC | RNA-seq and clinical data (TCGA. n = 351), scRNA-seq (GSE103322, n = 18) | PNI-associated coexpression module with 12 hub genes | PMID: 31214495 [14] |
| HNSCC | Multiomics and clinical data (TCGA, n = 361) | PNI-related gene expression profile (263 genes) | PMID: 30409320 [13] |
| OSCC | H&E- an ICH- stained whole-slide images (n = 142), NanoString Spatial Profiling | Spatial and transcriptomic analysis | PMID: 35819260 [15] |