Table 6.

Predicted ADMET for synthesized hybrids.

Comp. ID	PSA	PPB a	Absorption Level b	CYP2D6 Prediction c	BBB Level d	Solubility Level e	AlogP98
8	87.308	TRUE	2	FALSE	4	1	6
9	96.438	TRUE	2	FALSE	4	2	5.984
10	87.515	TRUE	2	FALSE	4	1	6.749
11	88.308	TRUE	2	FALSE	4	1	6.665
12	116.098	FALSE	2	FALSE	4	2	5.287
13	99.738	FALSE	2	FALSE	4	2	6.292
14	98.938	FALSE	2	FALSE	4	2	6.068
15	95.648	TRUE	2	FALSE	4	2	5.984
16	97.579	TRUE	2	FALSE	4	2	5.525
17	114.098	FALSE	2	FALSE	4	2	5.287
Erlotinib	71.052	TRUE	0	FALSE	1	2	4.309

^a PBB, plasma protein binding; FALSE means less than 90%; TRUE means > 90%. ^b Absorption level, 0 = good, 1 = moderate, 2 = poor, 3 = very poor. ^c CYP2D6, cytochrome P2D6; TRUE = inhibitor; FALSE = non-inhibitor. ^d BBB level, blood–brain barrier level, 0 = very high, 1 = high, 2 = medium, 3 = low, 4 = very low. ^e Solubility level, 1 = very low, 2 = low, 3 = good, 4 = optimal.