Table 7.
Predicted toxicity properties of synthesized hybrids.
| Comp. ID | FDA Rodent Carcinogenicity (Mouse–Female) |
Rat Maximum Tolerated Dose (Feed) a |
Rat Oral LD50 a |
Ocular Irritancy |
Skin Irritancy |
|---|---|---|---|---|---|
| 8 | Non-Carcinogenic | 0.271 | 0.871442 | Moderate | Non-Irritant |
| 9 | Non-Carcinogenic | 0.1722 | 1.35834 | Mild | Non-Irritant |
| 10 | Non-Carcinogenic | 0.1377 | 1.39385 | Moderate | Non-Irritant |
| 11 | Non-Carcinogenic | 0.2145 | 1.15043 | Moderate | Non-Irritant |
| 12 | Non-Carcinogenic | 0.1287 | 10.2483 | Mild | Non-Irritant |
| 13 | Non-Carcinogenic | 0.1108 | 2.4424 | Mild | Non-Irritant |
| 14 | Non-Carcinogenic | 0.1106 | 1.80353 | Mild | Non-Irritant |
| 15 | Non-Carcinogenic | 0.1722 | 1.35834 | Mild | Non-Irritant |
| 16 | Non-Carcinogenic | 0.1878 | 0.707581 | Mild | Non-Irritant |
| 17 | Non-Carcinogenic | 0.1287 | 10.2483 | Mild | Non-Irritant |
| Erlotinib | Non-Carcinogenic | 0.0828 | 0.662169 | Mild | Non-Irritant |
a Unit: g/kg body weight.