1. Study outcomes.
| Study | Comparison | Length of follow‐up | Time points of data presented |
Pressure Ulcer healed |
Adverse events | Change in ulcer size | Pressure ulcers severity | Wound infection and pain | Resource use | Cost |
| Dwivedi 2016 |
Group A: Negative pressure device (NPD) (N = 21) Group B: Wet‐to‐moist gauze dressings (n = 23) "nine patients withdrew from The NPWT group and seven from the control group." |
9 weeks |
1、2、3、4、5、6、7、8、9 weeks |
Not reported | Not reported | Data could not be used as they were reported as length, width, and depth The length and width were significantly decreased in Group A than in Group B from weeks 5 to 9 The depth was significantly decreased in Group A than in Group B at week 9 |
PUSH scores (reported as depth, exudate, and tissue type separately). | Not reported | Not reported | The total NPWT and SC cost of one representative PU was determined by multiplying the daily cost by the number of days required to achieve wound granulation. Group A: USD 105 Group B: USD 200 The total cost of a 9‐week treatment of one PU in Group B was significantly higher than Group A |
| Dwivedi 2017 |
Group A: NPWT (N=22) Group B: wet‐to‐moist gauze dressings (n = 22) "Ten participants were withdrawn from the NPWT group, and six participants withdrew from the comparison group and refused additional treatment. " |
9 weeks |
3、6、9 weeks |
Not reported | Not reported | Data could not be used as they were reported as length, width, and depth The length was significantly decreased in Group A than in Group B at week 6 and week 9 The width and depth were significantly decreased in Group A than in Group B at week 9 |
PUSH scores (reported as depth, exudate, and tissue type separately). | Not reported | Not reported | Not reported |
| Şahin 2022 |
Group A: NPWT (N = 15) Group B: wet‐to‐dry dressing (n = 15) |
8 weeks |
8 weeks |
Not reported | Not reported |
Change in wound size: Group A: mean ‐18.47 (SD 14.95); Group B: mean ‐3.8 (SD 14.95） |
Change in PUSH score: Group A: mean ‐4.597 (standard deviation 2.63); Group B: mean ‐1.067 (standard deviation 2.63） |
Not reported | Not reported | Not reported |
| Tang 2019 |
Group A: NPWT (N = 30) Group B: standard care (n = 30)； Including wound assessment, wound debridement, wet dressing, and health education |
3 month | 1、2、3 month | Not reported |
Not reported |
Number with 50% (or greater) reduction in wound size Group A: 16/30 Group B: 10/30 Rate of change in wound size Group A: mean ‐67.51 (SD 3.52); Group B: mean ‐52.75 (SD 4.52) |
Not reported |
Pain Group A: mean 3.04 (standard deviationSD 1.02); Group B: mean 4.19 (SD 0.37) The measurement time and method are not reported clearly |
Time of dressing change Group A: mean 11.06 (standard deviationSD 1.12); Group B: mean 37.36 (SD 5.24) |
Total dressing change cost Group A: RMB 35 000. 03 ± 15. 31 Group B: RMB 34993. 65 ± 16.39 |
| Ashby 2012 |
Group A: NPWT (n = 6) Group B: standard dressings (N = 6) "One of the following, chosen by the treating nurse: a spun hydrocolloid (fibrous hydrocolloid) dressing, a foam dressing or an alginate dressing (all non‐silver)" |
24 weeks | 24 weeks |
Group A: 1/6 Group B: 0/6 |
The number of participants with an AE: Group A: 5/6 Group B: 4/6 Serious AE (number of events): Group A: 4 Group B: 4 Non‐serious AE (number of events): Group A: 12 Group B: 8 |
Not reported | Not reported | Not reported | The number of trial treatment visits was reported but not extracted as the duration of treatments was different | Not reported |
|
de Laat 2011 |
Group A: NPWT (N = 6; 9 ulcers) Group B: conventional dressing therapy (n = 6; 7 ulcers) |
6 weeks | 6 weeks | Not reported |
Not reported for pressure ulcer group separately |
Number with 50% (or greater) reduction in wound size: Group A: 5/6 Group B: 5/6 Median treatment time in weeks until 50% wound volume reduction (IQR): Group A: 2 (1‐2) Group B: 3 (3‐4) |
Not reported | Not reported | Not reported |
Not reported |
| Ford 2002 |
Group A: NPWT Group B: Healthpoint system Total of 28 participants ‐ the number allocated to each group was not presented |
3‐10 months | Not clear what time point outcomes were presented for |
Group A: 2 ulcers healed Group B: 2 ulcers healed |
Not reported clearly: 1 lateral malleolar ulcer complicated by sepsis, requiring amputation |
Data reported on the Mean % reduction in volume could not be used as they were not clear if some participants had data considered in both trial groups | Not reported | Not reported | Not reported |
Not reported |
| Niezgoda 2004 |
Group A: NPWT (n = 54) Group B: moist wound healing (no further details) (n = 43) |
42 days | 42 days | Not reported |
Not reported |
Unadjusted Reported that wounds in Group A had a mean reduction in the area of 12.7cm² (SD 93.7). Wounds in Group B had a mean increase in the area of 23.5cm² (SD 261.2cm²). |
Not reported | Not reported | Not reported |
Mean cost of care per day (including materials, labour, debridements, and length of stay): Group A: USD 130 Group B: USD 132 No standard deviations reported |
Abbreviations
AE: adverse event(s); IQR: inter‐quartile range; NPWT: negative pressure wound therapy; SD: standard deviation