Figure 5.

Connexin (Cx43) orientation in the inner mitochondrial membrane. (A) Connexins localize to the inner mitochondrial membrane as single channels and/or in hexameric hemichannel structures. (B) The enlarged illustration of mitochondrial cristae depicts inner mitochondrial membrane-localized connexin oriented, such that extracellular loops extend into the matrix while carboxyl-terminal and N-terminal regions extend into the intermembrane space. The figure was produced using Procreate software version 5.3.2.