Figure 2.

Diverse signaling mechanisms through SCD1 in cancer stem cells. SCD1 is one of the target genes regulated by SREBP1. Decreased YAP phosphorylation resulting from SCD1 inhibition caused the disassembly of YAP in the nucleus, leading to a reduction in the expression of TEAD1 and cyclin D1. Post-translational acylation of the Wnt ligand, which MUFA mediates, enables its binding with the FZD4 receptor, resulting in the stabilization of β-catenin and leading to the expression of CSC regulatory genes.